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**** Zamchro is in receipt of the following warden message and would like to express disappoint on the actions taken by the DEC ***
Update on the Benadryl drug
Belliah made a comment explaining to our Zambian audience, what Benadryl is. Below is a full detailed definition:
BRAND NAME: Benadryl
DRUG CLASS AND MECHANISM: Diphenhydramine is an antihistamine used for treating allergic reactions. Histamine is released by the body during several types of allergic reactions and–to a lesser extent–during some viral infections, such as the common cold. When histamine binds to its receptors on cells, it stimulates changes within the cells that lead to sneezing, itching, and increased mucus production. Antihistamines compete with histamine for cell receptors; however, when they bind to the receptors they do not stimulate the cells. In addition, they prevent histamine from binding and stimulating the cells. Diphenhydramine also blocks the action of acetylcholine (anticholinergic effect) and is used as a sedative because it causes drowsiness. The FDA originally approved diphenhydramine in 1946.
GENERIC AVAILABLE: Yes
PREPARATIONS: Capsules: 25 and 50 mg. Tablets: 12.5, 25, and 50 mg. Strips: 12.5 and 25 mg. Elixir, oral solution, liquid: 12.5 mg per teaspoon (5 mL). Suspension: 25 mg per 5 ml. Injection: 50 mg per ml
b Diphenhydramine should be stored at room temperature, 15° to 30°C (59° to 86°F), and protected injection from freezing and light.
PRESCRIBED FOR: Diphenhydramine is used for the relief of nasal and non-nasal symptoms of various allergic conditions such as seasonal allergic rhinitis. It is also used to alleviate cold symptoms and chronic urticaria (hives). Although antihistamines are the preferred class of drugs in allergic rhinitis, they only reduce symptoms by 40%-60%. Diphenhydramine also is used for allergic reactions involving the eyes (allergic conjunctivitis), to prevent or treat active motion sickness, and for mild cases of Parkinsonism, including drug-induced Parkinsonism. The last two uses (motion sickness and Parkinsonism) are based on the anticholinergic effects of diphenhydramine, and not its antihistamine effects. Diphenhydramine is also used for treating insomnia.
DOSING: Diphenhydramine has its maximal effect about one hour after it is taken. When used to combat insomnia, it is prescribed at bedtime. Patients over the age of 60 years are especially sensitive to the sedating and anticholinergic effects of diphenhydramine, and the dose should be reduced. Doses vary depending on formulation. A common regimen for treating adult allergic reaction is 25-50 mg every 4-6 hours not to exceed 300 mg daily.
DRUG INTERACTIONS: Diphenhydramine adds to (exaggerates) the sedating effects of alcohol and other drugs than can cause sedation such as the benzodiazepine class of anti-anxiety drugs [for example, diazepam (Valium), lorazepam (Ativan), clonazepam (Klonopin), alprazolam (Xanax)], the narcotic class of pain medications and its derivatives [for example, oxycodone and acetaminophen (Percocet), and hydrocodone and acetaminophen (Vicodin), guaifenesin with hydromorphone (Dilaudid), Codeine, propoxyphene (Darvon)], the tricyclic class of antidepressants [for example, amitriptyline (Elavil), imipramine (Tofranil), desipramine (Norpramin)], and certain antihypertensive medications [for example, clonidine (Catapres), propranolol (Inderal)]. Diphenhydramine can also intensify the drying effects of other medications with anticholinergic properties [for example, dicyclomine (Bentyl), bethanechol (Urecholine), Probanthine].
PREGNANCY: Diphenhydramine has not been adequately evaluated in pregnant women. It should be used only if the benefit outweighs the potential but unknown risks.
NURSING MOTHERS: Diphenhydramine is secreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature infants, antihistamines should not be used by nursing mothers.
SIDE EFFECTS: Diphenhydramine can commonly cause sedation, tiredness, sleepiness, dizziness, disturbed coordination, drying and thickening of oral and other respiratory secretions, and stomach distress. Diphenhydramine may also cause low blood pressure, palpitations, increased heart rate, confusion, nervousness, irritability, blurred vision, double vision, tremor, loss or appetite, or nausea. Diphenhydramine should be used with caution (if at all) in persons with narrow-angle glaucoma, prostatic hypertrophy (enlarged prostate gland), hyperthyroidism, cardiovascular disease, hypertension, and asthma.
We will keep you posted: Hope the DEC reads
Previously we reported below:
US Embassy Lusaka
January 26, 2009
This message is intended for all American citizens visiting or residing in Zambia. The Embassy requests that wardens distribute the following notice to all American citizens within your registration zone as soon as possible. Thank you.
Recently, the Zambian Drug Enforcement Commission (DEC) has detained a number of Americans for possession of Benadryl and other over-the-counter medications which have contained small quantities of diphenhydramine, an active ingredient that is on Zambia’s list of controlled substances.
Although unaware of these restrictions, Americans have been charged with drug trafficking offenses, had their passports confiscated, and been jailed. As a result, any American visiting Zambia should consider leaving all non-prescription medications behind.
When traveling with prescription medications, Americans should bring a doctor’s prescription and ensure that the medication is in its original bottle. Any American stopped by the DEC for possession of over-the-counter medications should contact the Embassy at 0211-250-955 as soon as possible.
For the latest security information, Americans living and traveling abroad should regularly monitor the Department’s Bureau of Consular Affairs Internet website at http://travel.state.gov, where the current Worldwide Caution, Travel Alerts, and Travel Warnings can be found.
Up-to-date information can also be obtained by calling 1-888-407-4747 toll free in the U.S., or, for callers outside the U.S. and Canada, a regular toll line at 1-202-501-4444. These numbers are available from 8:00 AM to 8:00 PM Eastern time, Monday through Friday (except U.S. federal holidays).
The U.S. Embassy is located at the corner of Independence and United Nations Avenues. The mailing address is P.O. Box 31617, Lusaka, Zambia.
U.S. citizens may contact the American Embassy during regular work hours, Monday through Thursday from 7:30 AM to 5 PM, and on Friday from 7:30 AM to 12:30 PM by dialing 260-21-1-250-955. For after-hours emergencies involving American citizens, please dial 260-1-250-955 extension 1. The fax number is 260-21-1-252-225.
The website is: http://zambia.usembassy.gov